If you’re wondering about the best bet to make among the 14 NFL matchups in Week 5, we’re going with the Colts at +3 in terms of the point spreads. Don’t stop there, though — scroll down, because we have plenty more tips, which you could take advantage of in a parlay.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 5 Spread Bets

Jump to Matchup:

MIA-NE | BUF-HOU | TB-ATL | NYJ-MIN | BAL-CIN

Pick: Patriots -1 vs. Dolphins

• Matchup: Miami Dolphins at New England Patriots
• Projected Winner & Margin: Patriots by 4.0 points (Bet on this game at BetMGM)
• Spread: Patriots -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans +1 vs. Bills

• Matchup: Buffalo Bills at Houston Texans
• Projected Winner & Margin: Texans by 2.1 points (Bet on this game at BetMGM)
• Spread: Bills -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +1.5 vs. Falcons

• Matchup: Tampa Bay Buccaneers at Atlanta Falcons
• Projected Winner & Margin: Falcons by 0.7 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 8:15 p.m. ET
• Date: Oct. 3
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Jets

• Matchup: New York Jets vs. Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.2 points (Bet on this game at BetMGM)
• Spread: Vikings -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 6
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals +2.5 vs. Ravens

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Winner & Margin: Ravens by 1.2 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 5 Total Bets

Jump to Matchup:

Over 42.5 – Saints vs. Chiefs

• Matchup: New Orleans Saints at Kansas City Chiefs
• Projected Total: 45.1 points (Bet on this game at BetMGM)
• Time: 8:15 p.m. ET
• Date: Oct. 7
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 43 – Cowboys vs. Steelers

• Matchup: Dallas Cowboys at Pittsburgh Steelers
• Projected Total: 41.1 points (Bet on this game at BetMGM)
• Time: 8:20 p.m. ET
• Date: Oct. 6
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 43.5 – Buccaneers vs. Falcons

• Matchup: Tampa Bay Buccaneers at Atlanta Falcons
• Projected Total: 41.9 points (Bet on this game at BetMGM)
• Time: 8:15 p.m. ET
• Date: Oct. 3
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Under 50.5 – Ravens vs. Bengals

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Total: 50.0 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 48 – Packers vs. Rams

• Matchup: Green Bay Packers at Los Angeles Rams
• Projected Total: 47.9 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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